Does the relationship between kidney dysfunction and cardiovascular disease or mortality differ between high-risk patients with and without type 2 diabetes mellitus?
We aimed at comparing the relationship of reduced estimated glomerular filtration rate (eGFR) with cardiovascular disease (CVD) and mortality between high risk patients with and without type 2 diabetes mellitus (T2DM). The cross-sectional study evaluated 16,298 participants (1,627 T2DM) acutely admitted to hospital. The longitudinal study comprised 7,508 patients (673 with diabetes and 6,835 without). eGFR was categorized into 6 stages from >90 to P0.001) and kidney dysfunction (25% versus 13.2%;P0.001) than in the general population. An association with CVD was found with eGFR stages from 30 to 90 mL/min/1.73 m 2 in T2D and from P0.01for trend). Survival, in diabetes, was lower (P=0.037) but not associated with kidney dysfunction. Conclusions . In a high risk population, patients admitted to hospital, the relationship of kidney function with CVD is different between T2D and the general population. Competing mortality and the presence of other major risk factors in diabetes may be responsible for this difference.
Losito et al. (Fri,) studied this question.
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