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January 1, 2016International Journal of NephrologyOpen Access

Patients with T2D showed a higher prevalence of CVD (37.9% vs 23.6%; P<0.001) and kidney dysfunction (25% vs 13.2%; P<0.001) than the general population, but survival in diabetes was not associated with kidney dysfunction.

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Why the study?

Does the relationship between kidney dysfunction and cardiovascular disease or mortality differ between high-risk patients with and without type 2 diabetes mellitus?

Population

16,298 participants acutely admitted to hospital in the cross-sectional study, and 7,508 patients in the…

Comparison

Kidney dysfunction vs Normal kidney function and comparison between…

Design

Cohort

Authors

ALAttilio LositoUniversity of PerugiaLPLoretta PittaviniOspedale Santa MariaIZIvano ZampiUniversity of Perugia

Discussion

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Overview

Survival in T2D appears unrelated to kidney dysfunction despite higher CVD prevalence; leaves open differential prognostic impact versus non-diabetics.

Structured PICO

Does the relationship between kidney dysfunction and cardiovascular disease or mortality differ between high-risk patients with and without type 2 diabetes mellitus?

P
Population
16,298 participants (1,627 with type 2 diabetes mellitus) acutely admitted to hospital in the cross-sectional study, and 7,508 patients (673 with diabetes and 6,835 without) in the longitudinal study.
I
Intervention
Kidney dysfunction (defined by an eGFR < 60 mL/min/1.73 m²)
C
Comparator
Normal kidney function (eGFR ≥ 60 mL/min/1.73 m²) and comparison between patients with and without type 2 diabetes mellitus
O
Outcome
Cardiovascular disease (CVD) and mortalityhard clinical

Cite This Study

Losito et al. (2016) studied this question.

synapsesocial.com/papers/6a20023bd4e6d3589704ca87https://doi.org/10.1155/2016/7180784
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Also Consider

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  3. 3Major adverse cardiovascular events in people with chronic kidney disease in relation to disease severity and diabetes status2019 · 57 citations
  4. 4Cholesterol and Cardiovascular Risk in Type 2 Diabetes: The Role of Kidney Function2025 · 3 citations
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