Key result
An eGFR < 60 mL/min/1.73 m2 was associated with increased risk of incident CVD compared to eGFR ≥ 90 (HR 1.83; 95% CI 1.18-2.83; p=0.007), but this was no longer significant after full adjustment.
Why the study?
Does low eGFR (< 60 mL/min/1.73 m2) increase the risk of incident CVD and all-cause mortality compared to normal eGFR (≥ 90 ml/min/1.73 m2) in Iranian people with T2DM?
Cohort (n=802)
Does low eGFR (< 60 mL/min/1.73 m2) increase the risk of incident CVD and all-cause mortality compared to normal eGFR (≥ 90 ml/min/1.73 m2) in Iranian people with T2DM?
Hazard Ratio: 1.83 (95% CI 1.18–2.83)
p-value: p=0.007
In Iranian patients with T2DM, the apparent association between low eGFR and increased risk of CVD and mortality is largely explained by other covariates such as age and history of hypertension.
The association of estimated glomerular filtration rate (eGFR) with cardiovascular disease (CVD) and all-cause mortality among people with type two diabetes (T2DM) is less described. We aimed to investigate these associations in a population of Iranian people with T2DM. This retrospective cohort study included 802 individuals with T2DM who were free of CVD at baseline. Cox proportional hazard models were used to examine the associations of eGFR with CVD and all-cause mortality. During a Mean follow-up of 59.20 (± 24.58) months, 192 (23.9%) incident CVD and 53 (6.6%) death occurred. The risk of incident CVD and all-cause mortality was higher in individuals with eGFR < 60 mL/min/1.73 m 2 compared to the group with eGFR ≥ 90 ml/min/1.73 m 2 (HR: 1.83, 95%CI: 1.18–2.83; p = 0.007) and (HR: 7.81, 95%CI: 2.72–22.39; p = 0.000), respectively. The associations were not remain statistically significant in fully adjusted model. However, age and history of hypertension (HTN) were found as independent determinants of incident CVD and all-cause mortality. In this cohort of Iranian peple with T2DM, the association between low eGFR and increased risk of CVD and all-cause mortality was no longer sitatistically significant after adjustment for some potential CVD risk factors. The significant association of age and HTN with both CVD and all-cause mortality suggesting that these covariates account for a considerable portion of the observed excess risk. Moreover, residual confounding, particularly by unmeasured albuminuria, cannot be excluded.
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Hashemi-Madani et al. (2026) conducted a cohort in Type two diabetes mellitus (n=802). eGFR < 60 mL/min/1.73 m2 vs. eGFR ≥ 90 ml/min/1.73 m2 was evaluated on Incident cardiovascular disease (HR 1.83, 95% CI 1.18-2.83, p=0.007). An eGFR < 60 mL/min/1.73 m2 was associated with increased risk of incident CVD compared to eGFR ≥ 90 (HR 1.83; 95% CI 1.18-2.83; p=0.007), but this was no longer significant after full adjustment.
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