Key result
Hypertension is linked to ~36% higher odds of impaired eGFR.
Why the study?
The prevalence and interrelationships of reduced eGFR with diabetes, hypertension, and cardiovascular diseases in the Tabari cohort population were not well characterized.
Cross-Sectional (n=9,939)
Odds Ratio: 1.36 (95% CI 1.21–1.52)
p-value: p=<0.05
In an Iranian cohort, hypertension emerged as the strongest independent predictor of reduced eGFR, emphasizing the necessity of stringent blood pressure control to preserve renal function and limit combined cardiometabolic risk.
Background This study examines the prevalence and interrelationships of reduced estimated glomerular filtration rate (eGFR) with diabetes mellitus (DM), hypertension (HTN), and cardiovascular diseases (CVDs) within the Tabari cohort population. Methods A cross‐sectional analysis was performed using data from the Tabari cohort, part of the large Prospective Epidemiological Research Studies in Iran (PERSIAN) cohort study. Participants aged 35–70, excluding those with end‐stage renal disease or cancer, were included. Reduced eGFR was defined on the basis of a single baseline measurement of eGFR, categorized into G1–G4 stages. The presence of DM, HTN, and CVD was recorded along with demographic and clinical parameters. Statistical analyses included chi‐square tests, t ‐tests, and multiple logistic regressions. Results Of 9939 participants, 25.5% had reduced eGFR, with prevalence rates of 4.8%, 69.7%, 25.4%, and 0.1% for G1, G2, G3, and G4, respectively. Reduced eGFR was more common with increasing age, in females, and in single/divorced/widowed individuals ( p < 0.001). Higher prevalence was also observed among those with lower educational and socioeconomic status, urban residence, retirement or housewife occupational status, and elevated body mass index (BMI), waist circumference, triglycerides, and cholesterol ( p < 0.001). HTN, DM, and CVD were more frequent in individuals with reduced eGFR, with increasing prevalence across declining eGFR categories. After adjustment, HTN remained significantly associated with reduced eGFR (adjusted OR = 1.36, 95% CI: 1.21–1.52), whereas associations for DM and CVD were attenuated. Conclusion A high comorbid prevalence of HTN, DM, and CVD was observed among individuals with reduced eGFR in the Tabari cohort, with HTN emerging as the strongest independent predictor. These findings highlight the importance of early detection and integrated management strategies to prevent further decline in kidney function and associated complications.
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Hessami et al. (2026) conducted a cross-sectional in Impaired eGFR (Reduced kidney function) (n=9,939). Hypertension (and other cardiometabolic comorbidities) vs. Absence of hypertension was evaluated on Association of hypertension with impaired eGFR (eGFR < 60 mL/min/1.73 m2) after covariate adjustment (adjusted OR 1.36, 95% CI 1.21-1.52, p=<0.05). Hypertension remained a significant independent predictor of impaired estimated glomerular filtration rate (adjusted OR 1.36), whereas associations with diabetes and cardiovascular disease were attenuated after adjustment.
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