Filtered P-wave duration was an independent predictor of transition from paroxysmal to persistent atrial fibrillation (OR 2.71; 95% CI 1.78-4.13; p<0.01).
Cohort (n=102)
Do electrocardiographic and echocardiographic parameters predict the transition to persistent atrial fibrillation in patients with paroxysmal atrial fibrillation?
Filtered P-wave duration ≥ 150 ms and left atrial dimension ≥ 40 mm are clinically useful independent predictors of the progression from paroxysmal to persistent atrial fibrillation.
Odds Ratio: 2.71 (95% CI 1.78–4.13)
p-value: p=<0.01
BACKGROUND: Until now, no clinically useful indicators have existed that predict the transition from paroxysmal to persistent atrial fibrillation (AF). HYPOTHESIS: The current prospective study was conducted for identifying predictors of progression to persistent AF over the long term. METHODS: We studied 102 consecutive patients (mean age: 55 +/- 10 years: 75 men and 27 women) diagnosed with paroxysmal AF. Standard 12-lead electrocardiography, echocardiography, and P-wave-triggered signal-averaged electrocardiography (P-SAECG) were performed on all patients at the time of their entry into the study. RESULTS: The mean follow-up period was 61 +/- 13 months. Group 1 (n = 66) comprised patients in whom paroxysmal AF did not progress to persistent AF, and Group 2 (n = 36) comprised those who developed persistent AF. In Group 2 the patients were significantly older, and P-wave dispersion, filtered P-wave duration (FPD), and left atrial dimension were significantly higher than in Group 1 (p or = 40 mm predicted progression to persistent AF with a sensitivity of 64%, specificity of 76%, positive predictive value of 59%, negative predictive value of 79%, and an accuracy of 71%. An FPD > or = 150 ms predicted persistent AF with a sensitivity of 81%, specificity of 91%, positive predictive value of 88%, negative predictive value of 90%, and an accuracy of 87%. Filtered P-wave duration was a significantly more sensitive and specific predictor than left atrial dimension (p < 0.05). CONCLUSION: We conclude that FPD is a clinically useful predictor of progression from paroxysmal to persistent AF over the long term.
Koide et al. (Fri,) conducted a cohort in paroxysmal atrial fibrillation (n=102). Filtered P-wave duration (FPD) was evaluated on transition to persistent AF (OR 2.71, 95% CI 1.78-4.13, p=<0.01). Filtered P-wave duration was an independent predictor of transition from paroxysmal to persistent atrial fibrillation (OR 2.71; 95% CI 1.78-4.13; p<0.01).
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