In pediatric and young adult patients with bicuspid aortic valve, peak ascending aorta velocity strongly correlated with mean ascending aorta wall shear stress (r=0.84, P<0.001).
Observational (n=30)
How do 3D hemodynamics measured by 4D flow MRI correlate with aortic stenosis severity and echocardiography in pediatric and young adult patients with bicuspid aortic valve?
In pediatric and young adult BAV patients, aortic stenosis and peak ascending aorta velocity are associated with increased wall shear stress, while aortic dilation, age, and body surface area do not significantly impact hemodynamics.
Effect estimate: r = 0.84
p-value: p=<0.001
BACKGROUND: To evaluate the 3D hemodynamics in the thoracic aorta of pediatric and young adult bicuspid aortic valve (BAV) patients. METHODS: 4D flow MRI was performed in 30 pediatric and young adult BAV patients (age: 13.9 ± 4.4 (range: 3.4, 20.7) years old, M:F = 17:13) as part of this Institutional Review Board-approved study. Nomogram-based aortic root Z-scores were calculated to assess aortic dilatation and degree of aortic stenosis (AS) severity was assessed on MRI. Data analysis included calculation of time-averaged systolic 3D wall shear stress (WSSsys ) along the entire aorta wall, and regional quantification of maximum and mean WSSsys and peak systolic velocity (velsys ) in the ascending aorta (AAo), arch, and descending aorta (DAo). The 4D flow MRI AAo velsys was also compared with echocardiography peak velocity measurements. RESULTS: There was a positive correlation with both mean and max AAo WSSsys and peak AAo velsys (mean: r = 0.84, P < 0.001, max: r = 0.94, P < 0.001) and AS (mean: rS = 0.43, P = 0.02, max: rS = 0.70, P < 0.001). AAo peak velocity was significantly higher when measured with echo compared with 4D flow MRI (2.1 ± 0.98 m/s versus 1.27 ± 0.49 m/s, P < 0.001). CONCLUSION: In pediatric and young adult patients with BAV, AS and peak ascending aorta velocity are associated with increased AAo WSS, while aortic dilation, age, and body surface area do not significantly impact AAo hemodynamics. Prospective studies are required to establish the role of WSS as a risk-stratification tool in these patients.
Allen et al. (Thu,) conducted a observational in Bicuspid aortic valve (n=30). Aortic stenosis and peak ascending aorta velocity was evaluated on Correlation between peak ascending aorta velocity and mean ascending aorta wall shear stress (r = 0.84, p=<0.001). In pediatric and young adult patients with bicuspid aortic valve, peak ascending aorta velocity strongly correlated with mean ascending aorta wall shear stress (r=0.84, P<0.001).
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