Key result
Greater aortic stenosis severity strongly links to higher aortic wall shear stress in bicuspid aortic valves.
Cross-Sectional (n=30)
Effect estimate: rS = 0.70
p-value: p=<0.001
In pediatric patients with a bicuspid aortic valve, aortic stenosis severity is a primary driver of increased ascending aorta wall shear stress, independent of age or aortic dilation.
Aortic stenosis may drive ascending aorta WSS in young BAV patients; leaves open whether WSS modification improves outcomes in longitudinal studies.
BACKGROUND: To evaluate the 3D hemodynamics in the thoracic aorta of pediatric and young adult bicuspid aortic valve (BAV) patients. METHODS: 4D flow MRI was performed in 30 pediatric and young adult BAV patients (age: 13.9 ± 4.4 (range: [3.4, 20.7]) years old, M:F = 17:13) as part of this Institutional Review Board-approved study. Nomogram-based aortic root Z-scores were calculated to assess aortic dilatation and degree of aortic stenosis (AS) severity was assessed on MRI. Data analysis included calculation of time-averaged systolic 3D wall shear stress (WSSsys ) along the entire aorta wall, and regional quantification of maximum and mean WSSsys and peak systolic velocity (velsys ) in the ascending aorta (AAo), arch, and descending aorta (DAo). The 4D flow MRI AAo velsys was also compared with echocardiography peak velocity measurements. RESULTS: There was a positive correlation with both mean and max AAo WSSsys and peak AAo velsys (mean: r = 0.84, P < 0.001, max: r = 0.94, P < 0.001) and AS (mean: rS = 0.43, P = 0.02, max: rS = 0.70, P < 0.001). AAo peak velocity was significantly higher when measured with echo compared with 4D flow MRI (2.1 ± 0.98 m/s versus 1.27 ± 0.49 m/s, P < 0.001). CONCLUSION: In pediatric and young adult patients with BAV, AS and peak ascending aorta velocity are associated with increased AAo WSS, while aortic dilation, age, and body surface area do not significantly impact AAo hemodynamics. Prospective studies are required to establish the role of WSS as a risk-stratification tool in these patients.
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Allen et al. (2015) conducted a cross-sectional in Bicuspid aortic valve (BAV) (n=30). Aortic stenosis and peak velocity was evaluated on Correlation between aortic stenosis (AS) severity and maximum ascending aorta systolic wall shear stress (WSSsys) (rS = 0.70, p=<0.001). In pediatric and young adult patients with bicuspid aortic valve, aortic stenosis severity and peak ascending aorta velocity positively correlated with increased maximum ascending aorta wall shear stress (rS=0.70, P<0.001).
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