Comprehensive 4D flow MRI analysis of aortic flow hemodynamics in pediatric/young adult patients with bicuspid aortic valve

Bicuspid aortic valve is associated with progressive aortic dilatation, which is seen both in pediatric and adult populations. Although several studies have found a connection between aortic hemodynamics, vessel wall architectural abnormalities, and progressive dilation, the role of hemodynamics in pediatric aortopathy remains unclear. We used 4D flow MRI data in pediatric bicuspid aortic valve patients to identify potential hemodynamic biomarkers associated with aortic diameter. Despite no clear association with aortic diameter, different flow features between BAV patients with/without coarctation were found.