Participants with aortic valve sclerosis more commonly had larger clonal hematopoiesis of indeterminate potential clones than age- and sex-matched controls (P=0.027).
Case-Control
Is clonal hematopoiesis of indeterminate potential (CHIP) associated with the presence of aortic valve sclerosis?
Aortic valve sclerosis is associated with larger clones of clonal hematopoiesis of indeterminate potential (CHIP), suggesting a potential pathophysiological link.
p-value: p=0.027
Background: The mechanism and medical treatment target for degenerative aortic valve disease, including aortic stenosis, is not well studied. In this study, we investigated the effect of clonal hematopoiesis of indeterminate potential (CHIP) on the development of aortic valve sclerosis (AVS), a calcified aortic valve without significant stenosis. Methods: Participants with AVS (valves ≥2 mm thick, high echogenicity, and a peak transaortic velocity of <2.5 m/sec) and an age- and sex-matched control group were enrolled. Twenty-four CHIP genes with common variants in cardiovascular disease were used to generate a next-generation sequencing panel. The primary endpoint was the CHIP detection rate between the AVS and control groups. Inverse-probability treatment weighting (IPTW) analysis was performed to adjust for differences in baseline characteristics. Results: =0.027). This trend was concordant and clearer in the IPTW cohort. Conclusions: Participants with AVS more commonly had larger CHIP clones than age- and sex-matched controls. Further studies are warranted to identify causality between AVS and CHIP.
Kim et al. (Thu,) conducted a case-control in Aortic valve sclerosis. Clonal hematopoiesis of indeterminate potential (CHIP) vs. Age- and sex-matched controls was evaluated on CHIP detection rate between the AVS and control groups (p=0.027). Participants with aortic valve sclerosis more commonly had larger clonal hematopoiesis of indeterminate potential clones than age- and sex-matched controls (P=0.027).