Key result
Aortic valve sclerosis is linked to ~2.4-fold higher odds of CHIP variants.
Why the study?
The mechanism and medical treatment target for degenerative aortic valve disease, including aortic stenosis, are not well studied.
Is clonal hematopoiesis of indeterminate potential (CHIP) associated with the development of aortic valve sclerosis (AVS)?
Case-Control (n=187)
Blinded analysis
No
Is clonal hematopoiesis of indeterminate potential (CHIP) associated with the development of aortic valve sclerosis (AVS)?
Odds Ratio: 2.44 (95% CI 1.11–5.36)
Absolute Event Rate: 39.2% vs 21%
p-value: p=0.025
Patients with aortic valve sclerosis have a significantly higher prevalence of CHIP variants compared to age- and sex-matched controls, suggesting that CHIP-mediated inflammation may play a role in early degenerative aortic valve disease.
Higher CHIP prevalence in aortic valve sclerosis warrants no practice change; hypothesis-generating for causal role, needing prospective validation.
Background: The mechanism and medical treatment target for degenerative aortic valve disease, including aortic stenosis, is not well studied. In this study, we investigated the effect of clonal hematopoiesis of indeterminate potential (CHIP) on the development of aortic valve sclerosis (AVS), a calcified aortic valve without significant stenosis. Methods: Participants with AVS (valves ≥2 mm thick, high echogenicity, and a peak transaortic velocity of <2.5 m/sec) and an age- and sex-matched control group were enrolled. Twenty-four CHIP genes with common variants in cardiovascular disease were used to generate a next-generation sequencing panel. The primary endpoint was the CHIP detection rate between the AVS and control groups. Inverse-probability treatment weighting (IPTW) analysis was performed to adjust for differences in baseline characteristics. Results: =0.027). This trend was concordant and clearer in the IPTW cohort. Conclusions: Participants with AVS more commonly had larger CHIP clones than age- and sex-matched controls. Further studies are warranted to identify causality between AVS and CHIP.
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Kim et al. (2024) conducted a case-control in Aortic Valve Sclerosis (n=187). Aortic valve sclerosis vs. Age- and sex-matched controls without aortic valve sclerosis was evaluated on Detection rate of clonal hematopoiesis of indeterminate potential (CHIP) variants with a variant allele frequency ≥1% (adjusted OR 2.44, 95% CI 1.11-5.36, p=0.025). Participants with aortic valve sclerosis had a significantly higher prevalence of clonal hematopoiesis of indeterminate potential variants (VAF ≥1%).
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