Why the study?
CHIP confers a twofold risk of ASCVD, but there are limited data regarding specific cardiovascular phenotypes in this population.
Is the presence of CHIP mutations associated with an increased risk of left main coronary artery disease in patients undergoing coronary angiography?
Population
Patients recruited from a cardiac catheterization laboratory undergoing coronary angiography
Comparison
CHIP carriers vs non-CHIP carriers
Design
Observational study
Key result
Clonal hematopoiesis of indeterminate potential (CHIP) was significantly associated with any stenosis in the left main coronary artery (OR 1.87) compared to non-CHIP carriers.
Authors
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CHIP phenotypes in cath-lab patients need delineation; leaves open precise ASCVD mechanisms and risk stratification.
Observational (n=1,149)
Single-blind (personnel blinded to CHIP status)
No
Is the presence of CHIP mutations associated with an increased risk of left main coronary artery disease in patients undergoing coronary angiography?
Odds Ratio: 1.87 (95% CI 1.28–2.74)
p-value: p=0.0013
CHIP mutations, particularly TET2, are associated with an increased risk of left main coronary artery stenosis, providing a potential mechanism for enhanced ASCVD morbidity in this population.
Heimlich et al. (2023) conducted an observational in Coronary artery disease (n=1,149). Clonal hematopoiesis of indeterminate potential (CHIP) vs. Non-CHIP carriers was evaluated on Any stenosis in the left main (LM) coronary artery (OR 1.87, 95% CI 1.28-2.74, p=0.0013). Clonal hematopoiesis of indeterminate potential (CHIP) was significantly associated with any stenosis in the left main coronary artery (OR 1.87) compared to non-CHIP carriers.
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