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June 21, 2017New England Journal of MedicineOpen Access

Clonal Hematopoiesis and Risk of Atherosclerotic Cardiovascular Disease

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Authors

SJSiddhartha JaiswalPNPradeep NatarajanASAlexander J. Silver

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Overview

Randomized trial reveals increased coronary heart disease risk linked to clonal hematopoiesis in participants, suggesting potential biomarkers for cardiovascular health.

Key Points

  • This study examines the relationship between clonal hematopoiesis of indeterminate potential (CHIP) and the risk of atherosclerotic cardiovascular disease.
  • Utilized whole-exome sequencing to identify CHIP in peripheral-blood cells.
  • Analyzed data from four case-control studies involving 4726 participants with coronary heart disease and 3529 controls.
  • Conducted perturbation of Tet2 in atherosclerosis-prone mice to assess causality.
  • CHIP carriers exhibited a 1.9-fold increased risk of coronary heart disease compared to noncarriers (95% CI, 1.4 to 2.7).
  • Participants with CHIP had a 4.0-fold increased risk of early-onset myocardial infarction compared to noncarriers (95% CI, 2.4 to 6.7).
  • Tet2 knockout mice that received CHIP-derived bone marrow showed larger atherosclerotic lesions and elevated expression of genes related to atherosclerosis.

Cite This Study

Jaiswal et al. (2017) studied this question.

synapsesocial.com/papers/698cd08d2ce5fdb7c907f31bhttps://doi.org/10.1056/nejmoa1701719
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