Speckle Tracking in the Evaluation of Left Ventricular Dyssynchrony

A number of echocardiographic techniques have been introduced to determine left ventricular dyssynchrony (LVD) and to improve selection of patients for CRT. During the last years tissue Doppler imaging (TDI) has been used as the most preferred technique to quantify LVD, but results with nonresponder rates below 30% have been shown only in small studies based on high experience. Angle of incidence dependency, noise, artifacts, and tethering motion of adjacent segments are the main limitations of TDI influencing selection of patients for CRT. Although strain TDI is not affected by translation or tethering, accurate measurement of regional strain is also limited. Two-dimensional (2D) strain imaging based on novel speckle tracking echocardiography (STE) is a relatively new tool to define regional myocardial strain and to quantify dyssynchrony based on a more robust technique and avoiding angle of incidence. Current studies are promising to use strain or vector velocity imaging derived from STE for qualitative and quantitative assessment of LVD and follow-up studies as well. If one compare different types of strain components at present, radial strain imaging seems to be the most promising technique to determine LVD and to predict positive response to CRT. Furthermore, STE offers an insight into rotational mechanics of the dyssynchronous ventricle. Although clinical studies using 2D strain have analyzed LVD related to various conditions, measures are based on a 2D data set. Three-dimensional strain imaging, based on speckle tracking will probably open a new door to assess patients with heart failure and LVD.