This systematic review examines the functional role of arginine supplementation in the regulation of endothelial function and vascular tone across clinical and preclinical studies.
Systematic Review
Does arginine supplementation affect endothelial function and vascular tone in clinical and preclinical models of cardiovascular disease?
This systematic review examines the functional role of arginine supplementation in regulating endothelial function and vascular tone across various cardiovascular conditions.
Arginine (L-arginine), is an amino acid involved in a number of biological processes, including the biosynthesis of proteins, host immune response, urea cycle, and nitric oxide production. In this systematic review, we focus on the functional role of arginine in the regulation of endothelial function and vascular tone. Both clinical and preclinical studies are examined, analyzing the effects of arginine supplementation in hypertension, ischemic heart disease, aging, peripheral artery disease, and diabetes mellitus.
Gambardella et al. (Thu,) conducted a systematic review in Hypertension, ischemic heart disease, aging, peripheral artery disease, and diabetes mellitus. Arginine supplementation was evaluated on Endothelial function and vascular tone. This systematic review examines the functional role of arginine supplementation in the regulation of endothelial function and vascular tone across clinical and preclinical studies.
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