Key result
Arginine supplementation improves endothelial function by counteracting asymmetric dimethylarginine inhibition of nitric oxide synthase.
Why the study?
Does arginine supplementation improve endothelial function and vascular tone in patients with cardiovascular disorders?
Systematic Review
Does arginine supplementation improve endothelial function and vascular tone in patients with cardiovascular disorders?
Arginine supplementation represents a biologically plausible therapeutic strategy for counteracting endothelial dysfunction, particularly in patients with elevated ADMA levels.
Answers are grounded in this paper and cite their sources.
May support adjunctive arginine in endothelial dysfunction; extends ADMA-inhibition evidence to clinical cardiovascular settings.
Arginine (L-arginine), is an amino acid involved in a number of biological processes, including the biosynthesis of proteins, host immune response, urea cycle, and nitric oxide production. In this systematic review, we focus on the functional role of arginine in the regulation of endothelial function and vascular tone. Both clinical and preclinical studies are examined, analyzing the effects of arginine supplementation in hypertension, ischemic heart disease, aging, peripheral artery disease, and diabetes mellitus.
No takes yet. Share an insight, caveat, or question.
Gambardella et al. (2020) conducted a systematic review in Cardiovascular disorders (hypertension, ischemic heart disease, aging, peripheral artery disease, and diabetes mellitus). Arginine (L-arginine) supplementation was evaluated on Endothelial function and vascular tone. Arginine supplementation shows potential to improve endothelial function by overcoming the inhibitory effects of asymmetric dimethylarginine (ADMA) on nitric oxide synthase.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: