Insulin sensitivity was negatively correlated with common carotid maximum intima-media thickness in both high-risk (r = -0.45, P<0.05) and low-risk (r = -0.59, P<0.01) men.
Cross-Sectional (n=48)
Effect estimate: r = -.45 (high-risk), r = -.59 (low-risk)
p-value: p=<.05 (high-risk), <.01 (low-risk)
BACKGROUND AND PURPOSE: The aim of this investigation was to examine the relationship between insulin sensitivity and intima-media thickness in the common carotid artery. METHODS: Ultrasound examinations of the common carotid artery and hyperinsulinemic euglycemic clamp examinations were performed in a group (n = 25) of men aged 57 to 77 years at high risk for atherosclerotic disease (hypertension and at least one of the following factors: hypercholesterolemia and/or smoking) and in an age-matched low-risk group (n = 23) with no cardiovascular risk factors. Subjects with cardiovascular disease or diabetes mellitus were excluded. RESULTS: A significant negative relationship between insulin sensitivity index and common carotid maximum intima-media thickness was observed in both the high-risk group (r = -.45, P < .05) and in the low-risk group (r = -.59, P < .01). CONCLUSIONS: Our results suggest that an increase in intimamedia thickness, as a possible expression of early atherosclerosis, is negatively related to insulin sensitivity.
Agewall et al. (Thu,) conducted a cross-sectional in High and low coronary risk (n=48). Insulin sensitivity was evaluated on Relationship between insulin sensitivity index and common carotid maximum intima-media thickness (r = -.45 (high-risk), r = -.59 (low-risk), p=<.05 (high-risk), <.01 (low-risk)). Insulin sensitivity was negatively correlated with common carotid maximum intima-media thickness in both high-risk (r = -0.45, P<0.05) and low-risk (r = -0.59, P<0.01) men.
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