This review discusses evidence for the local production of renin-angiotensin system components in the heart and evaluates the role of alternative enzymes and prorenin uptake from the circulation.
The existence of a local renin-angiotensin system in the heart is still a controversial issue. This review discusses the evidence, obtained from studies in cardiac cells, in isolated perfused hearts and in intact animals and humans, both under normal and pathological conditions, for local production of prorenin, renin, angiotensinogen, angiotensin-converting enzyme, angiotensin I and angiotensin II at cardiac tissue sites. In addition, the role of alternative angiotensin-generating enzymes (cathepsin, chymase) and the possibility of (pro)renin uptake from the circulation is evaluated.
A.H. Jan Danser (Mon,) conducted a review in Local renin-angiotensin system in the heart. Local renin-angiotensin system was evaluated. This review discusses evidence for the local production of renin-angiotensin system components in the heart and evaluates the role of alternative enzymes and prorenin uptake from the circulation.