Key result
This review discusses evidence for the local production of renin-angiotensin system components in the heart and evaluates the role of alternative enzymes and prorenin uptake from the circulation.
Why the study?
Is there a local renin-angiotensin system in the heart?
Is there a local renin-angiotensin system in the heart?
This review evaluates the controversial evidence regarding the existence and functional role of a local renin-angiotensin system within the heart.
Evidence for cardiac RAS remains hypothesis-generating; leaves open its functional role and therapeutic relevance in humans.
The existence of a local renin-angiotensin system in the heart is still a controversial issue. This review discusses the evidence, obtained from studies in cardiac cells, in isolated perfused hearts and in intact animals and humans, both under normal and pathological conditions, for local production of prorenin, renin, angiotensinogen, angiotensin-converting enzyme, angiotensin I and angiotensin II at cardiac tissue sites. In addition, the role of alternative angiotensin-generating enzymes (cathepsin, chymase) and the possibility of (pro)renin uptake from the circulation is evaluated.
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A.H. Jan Danser (1999) conducted a review in Local renin-angiotensin system in the heart. Local renin-angiotensin system was evaluated. This review discusses evidence for the local production of renin-angiotensin system components in the heart and evaluates the role of alternative enzymes and prorenin uptake from the circulation.
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