Key result
Cyclic stretch increased myocyte protein synthesis by 20% but was not accompanied by angiotensin II release, indicating stretch-induced hypertrophy is independent of angiotensin II.
Population
Myocytes and fibroblasts isolated by enzymatic dissociation from hearts of 1-3-day-old Wistar rat strain pups
Comparison
Exposure to cyclic stretch for 24 h vs Basal conditions (no stretch)
Design
Preclinical
Follow-up
24 hours
Authors
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Questions autocrine Ang II release in stretched neonatal cardiomyocytes; leaves open RAS-independent hypertrophy mechanisms in adult human hearts.
Neonatal rat cardiomyocytes and fibroblasts do not synthesize renin or angiotensinogen, demonstrating that stretch-induced hypertrophy occurs independently of local Ang II synthesis.
Charlotte van Kesteren (1999) studied Cardiomyocyte hypertrophy. Cyclic stretch vs. Basal conditions was evaluated on Synthesis of renin-angiotensin system components and myocyte protein synthesis. Cyclic stretch increased myocyte protein synthesis by 20% but was not accompanied by angiotensin II release, indicating stretch-induced hypertrophy is independent of angiotensin II.
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