Key result
Mechanical stretch of neonatal rat cardiac myocytes upregulated the expression of Ang II type 1 and type 2 receptors by 2.8- and 3.3-fold, respectively, at 12 hours.
Why the study?
Does mechanical stretch increase the expression of Angiotensin II receptor subtypes in neonatal rat cardiac myocytes?
Population
1-day-old rat myocytes (in vitro stretch model)
Design
Preclinical
Follow-up
up to 18 hours
Authors
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May guide mechanistic studies of hypertrophy; leaves open clinical relevance in human disease.
Does mechanical stretch increase the expression of Angiotensin II receptor subtypes in neonatal rat cardiac myocytes?
Mechanical stretch upregulates AT1-R and AT2-R expression in neonatal rat cardiac myocytes via stretch-activated tyrosine kinases, enhancing Ang II responsiveness.
Kijima et al. (1996) studied Cardiac hypertrophy. Mechanical stretch vs. Unstretched myocytes was evaluated on Expression of Ang II type 1 and type 2 receptors. Mechanical stretch of neonatal rat cardiac myocytes upregulated the expression of Ang II type 1 and type 2 receptors by 2.8- and 3.3-fold, respectively, at 12 hours.
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