Why the study?
Does mechanical stretch/relaxation stimulate the cellular renin-angiotensin system in cultured rat mesangial cells?
Does mechanical stretch/relaxation stimulate the cellular renin-angiotensin system in cultured rat mesangial cells?
Mechanical stretch/relaxation stimulates the local renin-angiotensin system in cultured rat mesangial cells, providing a potential mechanism for pressure-induced glomerular injury.
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Mechanical stretch augments mesangial AT1R signaling in vitro; hypothesis-generating for pressure-induced glomerular injury and requires in vivo confirmation.
Becker et al. (1998) studied this question.
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