May 17, 2014Circulation Research

Stretch–Activation of Angiotensin II Type 1aReceptors Contributes to the Myogenic Response of Mouse Mesenteric and Renal Arteries

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Population

Mice deficient in AT1R signaling molecules and putative ion channel targets, and isolated mesenteric and…

Design

Preclinical

Authors

JSJohanna SchleifenbaumBerlin Institute of Health at Charité - Universitätsmedizin Berlin MKMario KaßmannUniversitätsmedizin Greifswald ISIstván András SzijártóMax Delbrück Center

Discussion

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Implication

Does not alter clinical vascular management; leaves open whether AT1R subtype a mechanosensing governs human myogenic tone.

Structured PICO

Population

Mice deficient in AT1R signaling molecules and putative ion channel targets (AT1R, angiotensinogen, TRPC6, or KCNQ3, 4, or 5), and isolated mesenteric and renal arteries/vascular smooth muscle cells.

Intervention

Osmotically induced membrane stretch and pharmacological block of AT1R or Kv channels (XE991)

Outcome

Myogenic response/vasoconstriction and ion channel currentssurrogate

The study identifies a ligand-independent mechanosensing mechanism in small arteries relying on AT1R subtype a to mediate the myogenic response.

Cite This Study

Schleifenbaum et al. (2014) studied this question.

synapsesocial.com/papers/6a6faeeb26a7f98052dc4ca8 https://doi.org/10.1161/circresaha.115.302882

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Stretch–Activation of Angiotensin II Type 1aReceptors Contributes to the Myogenic Response of Mouse Mesenteric and Renal Arteries

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Stretch–Activation of Angiotensin II Type 1aReceptors Contributes to the Myogenic Response of Mouse Mesenteric and Renal Arteries

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider