What is the clinical evidence from this study?

Study design: Other. Population: Dilated cardiomyopathy.

What does this research mean for the field?

Heightened FRET efficiency corresponds to lower, rather than higher, focal adhesion tension in vinculin FRET-tension sensor experiments. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To address errors in the interpretation of FRET efficiency related to focal adhesion tension in the original article.

June 7, 2026

Erratum for the Research Article “Preventing hypocontractility-induced fibro-blast expansion alleviates dilated cardiomyopathy”

Key Result

The erratum corrects the interpretation of FRET efficiency, clarifying that heightened FRET efficiency exhibits lower focal adhesion tension rather than higher tension.

Key Points

To address errors in the interpretation of FRET efficiency related to focal adhesion tension in the original article.
Correction of focal adhesion tension interpretation based on FRET efficiency findings.
Addition of more detailed methods for vinculin FRET-tension sensor experiments.
Inclusion of supporting references 89 and 90 in the materials and methods section.
Correction establishes that heightened FRET efficiency correlates with lower focal adhesion tension.
Text and figure revisions better reflect experimental findings and clarification of techniques used.

PICO

Population

Dilated cardiomyopathy

Abstract

In the Research Article “Preventing hypocontractility-induced fibroblast expansion alleviates dilated cardiomyopathy” by R. Bretherton et al. (11 September 2025, 10.1126/science.adv9157), the authors have corrected errors that arose from misinterpreting FRET efficiency. Heightened FRET efficiency exhibits lower focal adhesion tension, not higher focal adhesion tension as the original text indicated. The text and Fig. 3 legend have been revised accordingly. In addition, more detailed methods and two corresponding supporting references (references 89 and 90) have been added for vinculin FRET-tension sensor experiments (materials and methods section “Vinculin FRET measurements and analysis”).

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