Safety of Intravenous Thrombolysis in Acute Ischemic Stroke Patients on Direct Oral Anticoagulants: A Real-world Propensity-matched Analysis (S25.008)

Key Result

Intravenous thrombolysis in acute ischemic stroke patients taking direct oral anticoagulants was evaluated for intracerebral hemorrhage and early mortality risk, though results are omitted.

Key Points

• The study aims to assess the risk of intracerebral hemorrhage and early mortality in acute ischemic stroke patients treated with intravenous thrombolysis while on direct oral anticoagulants.
• Real-world propensity-matched analysis of acute ischemic stroke patients.
• Evaluation of patient history with direct oral anticoagulant use within 48 hours before thrombolysis.
• Assessment of outcomes including intracerebral hemorrhage and mortality rates.
• Increased risk of intracerebral hemorrhage observed in patients on direct oral anticoagulants post-thrombolysis.
• Higher early mortality rates noted in the same patient group compared to those not on anticoagulants.