Key result
IVT evaluation omits intracerebral hemorrhage and early mortality results in DOAC-treated acute ischemic stroke patients.
Why the study?
The risk of intracerebral hemorrhage and early mortality following intravenous thrombolysis in patients with acute ischemic stroke who took direct oral anticoagulants within 48 hours needed evaluation.
Does intravenous thrombolysis (IVT) affect the risk of intracerebral hemorrhage (ICH) and early mortality in patients with acute ischemic stroke (AIS) who had taken direct oral anticoagulants (DOACs) within 48 hours prior to symptom onset?
Does intravenous thrombolysis (IVT) affect the risk of intracerebral hemorrhage (ICH) and early mortality in patients with acute ischemic stroke (AIS) who had taken direct oral anticoagulants (DOACs) within 48 hours prior to symptom onset?
May support off-label IVT in selected patients; leaves open randomized confirmation of safety and efficacy.
To evaluate the risk of intracerebral hemorrhage (ICH) and early mortality following intravenous thrombolysis (IVT) in patients with acute ischemic stroke (AIS) who had taken direct oral anticoagulants (DOACs) within 48 hours prior to symptom onset.
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Andreão et al. (2026) studied this question. Intravenous thrombolysis in acute ischemic stroke patients taking direct oral anticoagulants was evaluated for intracerebral hemorrhage and early mortality risk, though results are omitted.
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