Intravenous Thrombolysis for Acute Ischemic Stroke in Patients With Recent Direct Oral Anticoagulant Use: A Systematic Review and Meta‐Analysis

Malik Ghannam; Mohammad Almajali; Milagros Galecio‐Castillo; Abdullah M. Al-Qudah; Farid Khasiyev; Mahmoud Dibas; Dana Ghazaleh; Juan Vivanco‐Suarez; Cristian Morán‐Mariños; Mudassir Farooqui; Aarón Rodríguez-Calienes; Prateeka Koul; Hannah Roeder; Hyungsub Shim; Edgar A. Samaniego; Enrique C. Leira; Harold P. Adams; Santiago Ortega‐Gutiérrez

doi:10.1161/jaha.123.031669

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Key Points

To evaluate the safety and functional outcomes of intravenous thrombolysis in acute ischemic stroke patients with recent direct oral anticoagulant use compared to non-users.
Systematic review and meta-analysis evaluating acute ischemic stroke patients treated with intravenous thrombolysis.
Compared hemorrhagic complications and functional independence rates between patients with recent direct oral anticoagulant (DOAC) exposure and non-DOAC users.
Patients with recent DOAC use receiving intravenous thrombolysis demonstrated similar rates of hemorrhagic complications compared to non-DOAC users (effect estimates not provided in abstract).
Functional independence outcomes were similar between DOAC-exposed and non-DOAC cohorts (effect estimates not provided in abstract).

Population

Patients with acute ischemic stroke treated with IVT

Comparison

Recent DOAC vs non-DOAC use

Design

Systematic review and meta-analysis

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Implication

Supports IVT in recent DOAC users with similar safety; leaves open confirmation by randomized trials.

Abstract

Patients with acute ischemic stroke treated with IVT in recent DOAC versus non-DOAC use have similar rates of hemorrhagic complications and functional independence. Further prospective randomized trials are warranted.

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Cite This Study

Ghannam et al. (2023) studied this question.

synapsesocial.com/papers/69d56e2975589c71d767d454 https://doi.org/10.1161/jaha.123.031669

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Intravenous Thrombolysis for Acute Ischemic Stroke in Patients With Recent Direct Oral Anticoagulant Use: A Systematic Review and Meta‐Analysis

Figures

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Intravenous Thrombolysis for Acute Ischemic Stroke in Patients With Recent Direct Oral Anticoagulant Use: A Systematic Review and Meta‐Analysis

Figures

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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