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This research aims to develop and evaluate a Carbopol-based hydrogel that incorporates Moringa oleifera root extract for diabetic wound management.

June 18, 2026Open Access

To develop and evaluate a Carbopol-based hydrogel containing Moringa oleifera root extract for antioxidant and antimicrobial diabetic wound management

Key Points

This research aims to develop and evaluate a Carbopol-based hydrogel that incorporates Moringa oleifera root extract for diabetic wound management.
Formulated six hydrogel variants (F1–F6) and assessed their physicochemical properties and drug release capabilities.
Evaluated antioxidant and antimicrobial activities of the hydrogels against diabetic wound conditions.
Batch F4 optimal with pH of 6.2, viscosity of 15800 cP, and 98% drug release in 6 hours.
Release kinetics followed Korsmeyer–Peppas model (R² = 0.9864), indicating non-Fickian diffusion.
Exhibited approximately 70% antioxidant activity and an antimicrobial zone of 24 mm.

Abstract

Background: Diabetic wounds are characterized by oxidative stress and infection, leading to delayed healing. Objective: To develop a Carbopol-based hydrogel incorporating Moringa oleifera root extract. Methods: Hydrogel formulations (F1–F6) were prepared and evaluated for physicochemical properties, drug release, antioxidant and antimicrobial activity. Results: Batch F4 showed optimal pH (6.2), viscosity (15800 cP), and 98% drug release within 6 hours. Release followed Korsmeyer–Peppas kinetics (R² = 0.9864), indicating non-Fickian diffusion. The formulation exhibited significant antioxidant (~70%) and antimicrobial activity (24 mm zone). Conclusion: The developed hydrogel demonstrates strong potential for diabetic wound management. Keywords: Carbopol hydrogel, Moringa oleifera, diabetic wound, antioxidant, antimicrobial, drug release

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