Each 10-point increase in the gestational modified Life's Essential 8 score was associated with a decreased risk of pregnancy loss (OR 0.85; 95% CI 0.76-0.95) and other adverse pregnancy outcomes.
Cohort (n=5,168)
Does a higher maternal cardiovascular health score (mLE8) reduce the risk of adverse pregnancy outcomes in pregnant women?
Higher maternal cardiovascular health in the first trimester, as assessed by the modified Life's Essential 8 score, is significantly associated with a lower risk of adverse pregnancy outcomes and slightly outperforms the older Life's Simple 7 metric.
Odds Ratio: 0.85 (95% CI 0.76–0.95)
BACKGROUND: The American Heart Association (AHA) has updated the definition of cardiovascular health (CVH) from "Life's Simple 7" (LS7) to "Life's Essential 8" (LE8). The association between gestational LE8 CVH status and adverse pregnancy outcomes is unclear. METHODS: We recruited pregnant women from the China birth cohort study during 6-13 RESULTS: Among the 5168 pregnant women finally included, the overall gestational mLE8 CVH score was 81.4 ± 9.6 points. After multivariate adjustment, each 10-points increase in the total overall gestational mLE8 CVH score was significantly associated with a decreased risk of pregnancy loss odds ratio (OR) = 0.85, 95% CI: 0.76-0.95), hypertensive disorders of pregnancy (OR = 0.50, 95% CI: 0.44-0.58), gestational diabetes mellitus (GDM) (OR = 0.62, 95% CI: 0.57-0.67), preterm birth (OR = 0.76, 95% CI: 0.67-0.86), large-for-gestational age (LGA) (OR = 0.81, 95% CI: 0.73-0.90), and cesarean delivery (OR = 0.77, 95% CI: 0.72-0.82). The areas under the ROC curves (AUC) of mLE8 were higher than those of LS7 for pregnancy loss (0.553 vs. 0.537, CONCLUSIONS: Higher gestational mLE8 CVH scores in the first trimester are significantly associated with a lower risk of adverse pregnancy outcomes. Although the capacity to predict adverse pregnancy outcomes was modest, mLE8 slightly outperformed LS7 in predicting PE, GDM, LGA, and cesarean delivery.
Gao et al. (Sun,) conducted a cohort in Adverse pregnancy outcomes (n=5,168). Modified Life's Essential 8 (mLE8) cardiovascular health score vs. Lower mLE8 score was evaluated on Pregnancy loss (OR 0.85, 95% CI 0.76-0.95). Each 10-point increase in the gestational modified Life's Essential 8 score was associated with a decreased risk of pregnancy loss (OR 0.85; 95% CI 0.76-0.95) and other adverse pregnancy outcomes.