General obesity was independently associated with increased left ventricular mass (β 10.04 g) and filling pressure, while abdominal obesity was associated with impaired left ventricular relaxation.
Cross-Sectional (n=971)
No
Are general and abdominal obesity associated with different patterns of left ventricular structural and functional alterations, and do these associations differ by sex?
General and abdominal obesity drive distinct patterns of left ventricular remodeling and diastolic dysfunction, highlighting the need to measure both BMI and waist circumference for heart failure risk assessment.
Mean Difference: 10.04 (95% CI 1.89–18.18)
p-value: p=0.02
AIMS: The current study aimed to evaluate the associations between general and abdominal obesity with left ventricular (LV) structure and function and whether these associations differed by sex. METHODS AND RESULTS: , and abdominal obesity was defined as waist circumference (WC) ≥ 90 cm for men and ≥85 cm for women. The associations between general and abdominal obesity with LV structure and function were examined using linear regression analysis, and the interaction by sex was performed. The mean age was 66.5 ± 11.4 years, and women accounted for 62%. General obese individuals (n = 205) were more likely to have concentric remodelling, LV hypertrophy, and worse diastolic function. Similar differences were observed in abdominal obese individuals (n = 593). General obesity was associated with LV end-diastolic volume, LV mass, left atrial volume, and septal E/e' ratio after adjusting for WC and clinical covariates; and abdominal obesity was associated with septal e' velocity after adjusting for BMI and clinical covariates. The associations between general obesity with LV structure and function did not differ by sex, while the magnitudes of the associations between abdominal obesity with LV mass and septal e' velocity were greater in men. CONCLUSIONS: General and abdominal obesity were associated with different patterns of LV structural and functional alterations, stressing the importance of incorporating BMI and WC measurements into assessing obesity-related LV alterations.
Cai et al. (Wed,) conducted a cross-sectional in Hypertension without overt cardiovascular disease (n=971). General and abdominal obesity vs. Non-obese individuals was evaluated on Left ventricular mass (LVM) (β 10.04, 95% CI 1.89-18.18, p=0.02). General obesity was independently associated with increased left ventricular mass (β 10.04 g) and filling pressure, while abdominal obesity was associated with impaired left ventricular relaxation.
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