Characterisation of the Novel HLA-DRB1*11:365 Allele by Sequencing-Based Typing.

Key Points

• The central aim is to describe the HLA-DRB1*11:365 allele and its genetic differences from HLA-DRB1*11:04:01:01.
• Utilized sequencing-based typing to identify genetic variations.
• Compared HLA-DRB1*11:365 allele with HLA-DRB1*11:04:01:01.
• Focused on codon 223 in exon 4 for nucleotide analysis.
• HLA-DRB1*11:365 possesses a single nucleotide substitution at codon 223.
• This allele variation is confirmed through detailed sequencing.
• The study highlights the genetic uniqueness of HLA-DRB1*11:365.