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July 1, 2026

Characterisation of the Novel HLA-DRB1*11:365 Allele by Sequencing-Based Typing.

Thibault Pajot Isabelle Top B. Proust C Humeau Vincent Elsermans

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Key Points

The central aim is to describe the HLA-DRB1*11:365 allele and its genetic differences from HLA-DRB1*11:04:01:01.
Utilized sequencing-based typing to identify genetic variations.
Compared HLA-DRB1*11:365 allele with HLA-DRB1*11:04:01:01.
Focused on codon 223 in exon 4 for nucleotide analysis.
HLA-DRB1*11:365 possesses a single nucleotide substitution at codon 223.
This allele variation is confirmed through detailed sequencing.
The study highlights the genetic uniqueness of HLA-DRB1*11:365.

Implication

Characterizes the HLA-DRB1*11:365 allele, revealing its distinct nucleotide substitution in exon 4.

Abstract

HLA-DRB1*11:365 differs from HLA-DRB1*11:04:01:01 by one nucleotide substitution in codon 223 in exon 4.

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Cite This Study

Pajot et al. (2026) studied this question.

synapsesocial.com/papers/6a4754965c29257aa257a152 https://doi.org/10.1111/tan.70842

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