At a steady state far from equilibrium, the force exerted by individual myosin cross-bridges can generate a nonzero average isometric force that far exceeds the macroscopic phase-transition force.
Theoretical analysis suggests that an equilibrium phase transition cannot be the basic feature in muscular contraction because isometric force decreases linearly with increasing length.
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Terrell L. Hill (Sun,) conducted a other in Muscular contraction (theoretical model). Theoretical thermodynamic and kinetic modeling was evaluated. At a steady state far from equilibrium, the force exerted by individual myosin cross-bridges can generate a nonzero average isometric force that far exceeds the macroscopic phase-transition force.