Figure S7 from Pancreatic Neuroendocrine Tumors Secrete Apolipoprotein E to Induce Tip Endothelial Cells That Remodel the Tumor–Stroma Ratio and Promote Cancer Progression

Puntos clave

• Apolipoprotein E from pancreatic neuroendocrine tumors influences endothelial cells to alter tumor–stroma ratio.
• mTOR inhibitors combined with PEGPH20 significantly improve treatment effects in tumor progression.
• The interaction between cancer cells and the stroma plays a vital role in shaping tumor development.
• Findings may lead to new therapeutic strategies targeting the tumor microenvironment in cancer.