Table S8 from RGN6024 Is a Brain-Penetrant, Small-Molecule Tubulin Destabilizer for the Treatment of Glioblastoma

Puntos clave

• RGN6024 shows significant potential as a tubulin destabilizer for glioblastoma treatment.
• In a xenograft model, RGN6024 effectively penetrates the brain, enabling therapeutic action.
• Tumor and plasma levels of RGN6024 were measured to assess its pharmacokinetics and efficacy.
• This research contributes to developing targeted therapies for glioblastoma, a challenging brain cancer.