Figure S2 from B7-H3 CAR T Cells Are Effective against Ependymomas but Limited by Tumor Size and Immune Response

Puntos clave

• B7-H3 CAR T cells demonstrate effectiveness against ependymomas, but their impact is limited by tumor size and immune responses.
• Figure S2 reveals the regulation of B7-H3 transcriptional activity by the ZFTA-RELA oncogene, providing insight into therapeutic targets.
• The findings stress the importance of tumor characteristics, including size and immune response, in the efficacy of CAR T cell therapies.
• The study indicates a need for strategies to enhance the effectiveness of CAR T cells against larger tumors and in the context of immune challenges.