Figure 2 from Tumor-Intrinsic Activity of Chromobox 2 Remodels the Tumor Microenvironment in High-grade Serous Carcinoma

CBX2 regulates immune-related pathways in a tumor cell–intrinsic fashion. A, Carcinoma EcoTyper epithelial states (S1–6) compared with CBX2 expression (top panel) and cytokine–cytokine receptor interaction pathway. B, Correlation (x-axis, rho) of CBX2 mRNA expression in 303 HGSC tumors with imputed cell type. Adjusted P value shown on y-axis. Imputation pipeline (e. g. , CIBERSORT and TIDE) utilized follows underscore in title of plot (details included in Supplementary Table S4). C, Scatter plot of CBX2 mRNA expression and macrophage M2TIDE. D, Scatter plot of CBX2 mRNA expression and MDSCTIDE. E, Scatter plot of CBX2 mRNA expression and Macrophage M0CIBERSORT. F, Scatter plot of CBX2 mRNA expression and T cell CD4+ effector memoryXCELL. G, An annotated tissue microarray was used to perform mIHC evaluating CBX2 expression and immune cell types. Plot demonstrating the relationship between % stromal CD68+/pStat3+ and CBX2 H-score. Statistical tests, unpaired t test (C) and Pearson correlation (D–G).