Peptides are short chains of amino acids they possess unique properties such as their diversity in structure, tunable Hydrophobicity/Hydrophilicity and their inherent Bio compatibility. Peptide-based drug delivery systems (PBDDS) have emerged as versatile systems bridging small molecules and biologics. Over the last decade, innovations in peptide chemistry, self-assembly, conjugation strategies, and targeting strategies have transformed peptides from passive excipients used into active delivery vehicles. This review focuses on peptide drug conjugates (PDCs), cell-penetrating peptides (CPPs), self-assembled nanostructures, hybrid nanoparticles and hydrogels. Also gives an insight on transitional challenges including stability and immunogenicity, including Opportunities in AI-guided peptide design, oral/transmucosal delivery.
Reddy et al. (Wed,) studied this question.
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