Severe bicuspid aortic valve stenosis had similar LGE prevalence to tricuspid stenosis (OR 2.6; 95% CI 0.7-11; p=0.17), but a 1.6-percentage point higher LGE volume (95% CI 0.02-3.3; p=0.047).
Observational (n=80)
Does severe bicuspid aortic valve stenosis compared to tricuspid aortic valve stenosis show differences in myocardial fibrosis on cardiac magnetic resonance?
Patients with severe bicuspid and tricuspid aortic stenosis have similar overall prevalence of myocardial fibrosis on CMR, though bicuspid patients may have a slightly higher LGE burden.
Estimación del efecto: OR 2.6 (95% CI 0.7 to 11)
valor p: p=0.17
Abstract Background Myocardial fibrosis is common in aortic valve stenosis (AS) and has been proposed as a marker in the timing of aortic valve replacement. Aims We aimed to explore differences in the prevalence and degree of myocardial fibrosis between patients with severe bicuspid AS (BAV-AS) and tricuspid AS (TAV-AS), as potential differences may have implications for its clinical implementation. Methods and results Cardiac magnetic resonance was performed in 80 patients with severe symptomatic AS planned to undergo AVR (48% bicuspid valve, 74% male, mean age 69±11years) with evaluation of native T1, extracellular volume fraction (ECV%), and late gadolinium enhancement (LGE). Results When comparing patients with TAV-AS to those with BAV-AS and adjusting for sex, age, and aortic peak velocity, there were no differences in native T1 (mean difference MD 10 ms; 95% confidence interval CI -5 to 25; p=0.18), ECV% (MD 1.2; 95% CI -0.2 to 2.7; p=0.10), nor the prevalence of LGE (OR 2.6; 95% CI 0.7 to 11; p=0.17). However, BAV-AS patients had a 1.6-percentage point higher LGE volume percentage compared with TAV-AS patients (95% CI 0.02 to 3.3; p=0.047). Conclusions Patients with severe BAV-AS and TAV-AS exhibited similar values of native T1, ECV%, and LGE prevalence. However, the LGE burden was slightly higher in BAV-AS.
Myhr et al. (Tue,) conducted a observational in Severe symptomatic aortic valve stenosis (n=80). Bicuspid aortic valve stenosis (BAV-AS) vs. Tricuspid aortic valve stenosis (TAV-AS) was evaluated on Prevalence of late gadolinium enhancement (LGE) (OR 2.6, 95% CI 0.7 to 11, p=0.17). Severe bicuspid aortic valve stenosis had similar LGE prevalence to tricuspid stenosis (OR 2.6; 95% CI 0.7-11; p=0.17), but a 1.6-percentage point higher LGE volume (95% CI 0.02-3.3; p=0.047).
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