Poliomyelitis viruses (Types 1 and 2) successfully propagated in and destroyed monkey testicular fibroblasts in vitro, an effect neutralized by type-specific antibodies.
Monkey testicular fibroblasts can support the in vitro growth of poliomyelitis viruses, leading to cell destruction that is preventable by specific antibodies.
Cells like fibroblasts, having no resemblance whatever to nerve cells were obtained in morphologically pure cultures from monkey testicular tissue and were found to support the growth in vitro of poliomyelitis virus, Type 2, Yale-SK strain. Moreover, these cells were destroyed as a result of the multiplication of this virus within them. Similarly, "fibroblasts" propagated in primary explant cultures of testicle were destroyed by poliomyelitis viruses, Types 1 and 2. Type specific antibodies neutralized the pathogenic effect of poliomyelitis virus on monkey testicular fibroblasts.
Scherer et al. (Wed,) conducted a other in Poliomyelitis virus. Poliomyelitis virus, Types 1 and 2 was evaluated on Viral propagation and cell destruction. Poliomyelitis viruses (Types 1 and 2) successfully propagated in and destroyed monkey testicular fibroblasts in vitro, an effect neutralized by type-specific antibodies.
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