ATX-Lp(a) levels were significantly associated with calcific aortic valve stenosis in a multivariable model corrected for risk factors (p = 0.003).
Case-Control (n=232)
Is ATX-Lp(a) associated with calcific aortic valve stenosis?
ATX is preferentially transported by Lp(a) and ATX-Lp(a) levels are associated with calcific aortic valve stenosis, suggesting its potential as a novel biomarker.
valor p: p=0.003
Our objectives were to determine whether autotaxin (ATX) is transported by lipoprotein(a) Lp(a) in human plasma and if could be used as a biomarker of calcific aortic valve stenosis (CAVS). We first found that ATX activity was higher in Lp(a) compared to low-density lipoprotein fractions in isolated fractions of 10 healthy participants. We developed a specific assay to measure ATX-Lp(a) in 88 patients with CAVS and 144 controls without CAVS. In a multivariable model corrected for CAVS risk factors, ATX-Lp(a) was associated with CAVS (p = 0.003). We concluded that ATX is preferentially transported by Lp(a) and might represent a novel biomarker for CAVS.
Bourgeois et al. (Wed,) conducted a case-control in Calcific Aortic Valve Stenosis (CAVS) (n=232). Autotaxin-Lipoprotein(a) [ATX-Lp(a)] vs. Controls without CAVS was evaluated on Association with CAVS (p=0.003). ATX-Lp(a) levels were significantly associated with calcific aortic valve stenosis in a multivariable model corrected for risk factors (p = 0.003).
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