Abstract INTRODUCTION: This collaborative study aims to present the results obtained from the implementation of the Hematopoietic Cell Transplantation Frailty Scale (HCT-FS) for the assessment of frailty in adult candidates for allogeneic hematopoietic cell transplantation (allo-HCT) at 16 independent HCT Units.METHODS: Sixteen allo-HCT programs (1 in Canada, 15 in Spain) participated. Frailty was systematically assessed at the first allo-HCT consultation using the HCT-FS (https://hctfrailtyscale.com) and incorporated into routine clinical practice at each center without external funding.RESULTS: A total of 1,077 consecutive adult allo-HCT candidates (median age: 56 years) were evaluated. Based on the HCT-FS, 33.4% were classified as fit, 53.7% as pre-frail, and 12.8% as frail. Frailty was associated with longer hospital stays during allo-HCT (28 days vs. 23 and 25; P = 0.003) and higher ICU admission rates by day + 180 (20.3% vs. 7.0% and 10.8%; P = 0.002). Two-year OS decreased progressively with increasing frailty: 77.2% in fit, 65.7% in pre-frail, and 52.8% in frail patients (P CONCLUSION: The HCT-FS provides reliable measures of the frailty status of allo-HCT candidates that are informative in anticipating transplant outcomes, particularly risk of OS. Its use is recommended in clinical practice for pre-transplant assessments.
Salas et al. (Sun,) studied this question.
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