Figure S6 from Direct Co-Targeting of Bcl-xL and Mcl-1 Exhibits Synergistic Effects in AR-V7–Expressing CRPC Models

Key Points

• Combination therapy with BH3 mimetics shows enhanced effects in targeting multiple cancer pathways.
• The treatment of 3D spheroids revealed synergistic interactions between the agents, leading to better outcomes.
• This approach utilizes AR-V7-expressing CRPC models to assess treatment effectiveness.
• Further exploration of these results may inform new therapeutic strategies for resistant cancer forms.