Figure S6 from Direct Co-Targeting of Bcl-xL and Mcl-1 Exhibits Synergistic Effects in AR-V7–Expressing CRPC Models

This is a In Vitro Study study.

Key Points

Combination therapy with BH3 mimetics shows enhanced effects in targeting multiple cancer pathways.
The treatment of 3D spheroids revealed synergistic interactions between the agents, leading to better outcomes.
This approach utilizes AR-V7-expressing CRPC models to assess treatment effectiveness.
Further exploration of these results may inform new therapeutic strategies for resistant cancer forms.

Observational analysis shows improved treatment effects with BH3 mimetics in AR-V7-expressing CRPC, indicating potential for combination therapy.

Figure S6 shows the effect of treamtent of 3D spheroids with BH3 mimetics as single agents or in combination.

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Brim et al. (2025) studied this question.

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