Figure S3 from Direct Co-Targeting of Bcl-xL and Mcl-1 Exhibits Synergistic Effects in AR-V7–Expressing CRPC Models

Key Points

• Co-treatment significantly enhances cancer cell death in AR-V7-expressing models, indicating potent synergistic effects.
• The combination led to a greater reduction in viability compared to individual treatments, showcasing the potential for improved efficacy.
• Assessment using 2D culture models reveals the interactions between venetoclax and S63845 under controlled conditions.
• These findings may support further exploration of combined therapies in CRPC management.