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August 21, 2025Open Access

Figure S3 from Direct Co-Targeting of Bcl-xL and Mcl-1 Exhibits Synergistic Effects in AR-V7–Expressing CRPC Models

Benjamin C. Brim Andres F. Leon Erica L. Beatson Jessica D. Kindrick Kinjal Bhadresha Xiaohu Zhang Giulia C. Napoli Emily N. Risdon Keith T. Schmidt Kelli M. Wilson Crystal McKnight Erin Beck Carleen Klumpp‐Thomas Michele Ceribelli JuanJuan Yin Adam G. Sowalsky Douglas K. Price Cindy H. Chau Craig J. Thomas William D. Figg

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Key Points

Co-treatment significantly enhances cancer cell death in AR-V7-expressing models, indicating potent synergistic effects.
The combination led to a greater reduction in viability compared to individual treatments, showcasing the potential for improved efficacy.
Assessment using 2D culture models reveals the interactions between venetoclax and S63845 under controlled conditions.
These findings may support further exploration of combined therapies in CRPC management.

Implication

Co-treatment with venetoclax and S63845 improves outcomes in AR-V7-expressing CRPC, suggesting a new therapeutic strategy.

Abstract

Figure S3 shows the effects of co-treatment of venetoclax with S63845 across 2D culture.

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Cite This Study

Brim et al. (2025) studied this question.

synapsesocial.com/papers/68af56f4ad7bf08b1eadce99 https://doi.org/10.1158/2767-9764.29957543

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Figure S5 from Direct Co-Targeting of Bcl-xL and Mcl-1 Exhibits Synergistic Effects in AR-V7–Expressing CRPC Models2025
2Figure S8 from Direct Co-Targeting of Bcl-xL and Mcl-1 Exhibits Synergistic Effects in AR-V7–Expressing CRPC Models2025
3Figure S9 from Direct Co-Targeting of Bcl-xL and Mcl-1 Exhibits Synergistic Effects in AR-V7–Expressing CRPC Models2025
4Figure S6 from Direct Co-Targeting of Bcl-xL and Mcl-1 Exhibits Synergistic Effects in AR-V7–Expressing CRPC Models2025
5Figure S4 from Direct Co-Targeting of Bcl-xL and Mcl-1 Exhibits Synergistic Effects in AR-V7–Expressing CRPC Models2025