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August 21, 2025Open Access

Table S2 from Direct Co-Targeting of Bcl-xL and Mcl-1 Exhibits Synergistic Effects in AR-V7–Expressing CRPC Models

Benjamin C. Brim Andres F. Leon Erica L. Beatson Jessica D. Kindrick Kinjal Bhadresha Xiaohu Zhang Giulia C. Napoli Emily N. Risdon Keith T. Schmidt Kelli M. Wilson Crystal McKnight Erin Beck Carleen Klumpp‐Thomas Michele Ceribelli JuanJuan Yin Adam G. Sowalsky Douglas K. Price Cindy H. Chau Craig J. Thomas William D. Figg

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Key Points

Co-targeting of bcl-xl and mcl-1 shows synergistic effects in AR-V7-expressing CRPC models, which enhances treatment efficacy.
IC50 values for BH3 mimetics identified in Table S2 indicate their activity as single agents in both 2D culture and 3D spheroids.
Assessment of drug interactions aligns with methods comparing impact across different cellular models, demonstrating effectiveness.
Clinical implications arise for future CRPC therapies, as targeting both proteins may improve patient outcomes in prostate cancer.

Implication

Table S2 compares IC50 values of BH3 mimetics in 2D culture and 3D spheroids, suggesting combined therapy benefits.

Abstract

Table S2 compares the IC50 values of BH3 mimetics as single agents across 2D culture and 3D spheroids.

Discussion

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Cite This Study

Brim et al. (2025) studied this question.

synapsesocial.com/papers/68af56f4ad7bf08b1eadce90 https://doi.org/10.1158/2767-9764.29957519

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Table S1 from Direct Co-Targeting of Bcl-xL and Mcl-1 Exhibits Synergistic Effects in AR-V7–Expressing CRPC Models2025
2Figure S6 from Direct Co-Targeting of Bcl-xL and Mcl-1 Exhibits Synergistic Effects in AR-V7–Expressing CRPC Models2025
3Figure S2 from Direct Co-Targeting of Bcl-xL and Mcl-1 Exhibits Synergistic Effects in AR-V7–Expressing CRPC Models2025
4Figure S5 from Direct Co-Targeting of Bcl-xL and Mcl-1 Exhibits Synergistic Effects in AR-V7–Expressing CRPC Models2025
5Figure S8 from Direct Co-Targeting of Bcl-xL and Mcl-1 Exhibits Synergistic Effects in AR-V7–Expressing CRPC Models2025