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August 21, 2025Open Access

Table S1 from Direct Co-Targeting of Bcl-xL and Mcl-1 Exhibits Synergistic Effects in AR-V7–Expressing CRPC Models

Benjamin C. Brim Andres F. Leon Erica L. Beatson Jessica D. Kindrick Kinjal Bhadresha Xiaohu Zhang Giulia C. Napoli Emily N. Risdon Keith T. Schmidt Kelli M. Wilson Crystal McKnight Erin Beck Carleen Klumpp‐Thomas Michele Ceribelli JuanJuan Yin Adam G. Sowalsky Douglas K. Price Cindy H. Chau Craig J. Thomas William D. Figg

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Key Points

Synergistic effects were observed when targeting both Bcl-xL and Mcl-1 in CRPC models, indicating enhanced treatment potential.
The study reported IC50 values for BH3 mimetics as single agents in 2D models, showcasing their potential efficacy.
Assessment using BH3 mimetics demonstrated enhanced anti-cancer effects on AR-V7-expressing CRPC tumors.
Findings support the need for combination treatments targeting Bcl-xL and Mcl-1 to optimize therapy in CRPC models.

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Implication

Co-targeting Bcl-xL and Mcl-1 improved effects in CRPC cell models, suggesting a new treatment approach.

Abstract

Table S1 depicts the IC50 values of BH3 mimetics as single agents in 2D models.

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Cite This Study

Brim et al. (2025) studied this question.

synapsesocial.com/papers/68af56f4ad7bf08b1eadce9b https://doi.org/10.1158/2767-9764.29957522

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Table S2 from Direct Co-Targeting of Bcl-xL and Mcl-1 Exhibits Synergistic Effects in AR-V7–Expressing CRPC Models2025
2Figure S2 from Direct Co-Targeting of Bcl-xL and Mcl-1 Exhibits Synergistic Effects in AR-V7–Expressing CRPC Models2025
3Figure S6 from Direct Co-Targeting of Bcl-xL and Mcl-1 Exhibits Synergistic Effects in AR-V7–Expressing CRPC Models2025
4Figure S5 from Direct Co-Targeting of Bcl-xL and Mcl-1 Exhibits Synergistic Effects in AR-V7–Expressing CRPC Models2025
5Figure S8 from Direct Co-Targeting of Bcl-xL and Mcl-1 Exhibits Synergistic Effects in AR-V7–Expressing CRPC Models2025