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September 17, 2025

Diagnostic Value of Combined IVIM, DKI, and DCE-MRI in Differentiating Benign and Malignant Breast Lesions

Key Points

The combined imaging model shows superior diagnostic efficacy in distinguishing breast lesions.
Higher Ktrans, Kep, and MK values indicate malignant lesions, while lower D and MD values suggest benign ones.
Using ROC analysis, MRI parameters effectively differentiate between lesion types.
Enhanced diagnostic precision may lead to improved clinical decision-making for breast cancer treatments.

Abstract

Motivation: Non-invasive imaging like IVIM, DKI, and DCE-MRI improves diagnostic accuracy by revealing tissue characteristics and aiding differentiation of benign and malignant breast lesions. Goal(s): This study assesses the diagnostic value of a combined IVIM, DKI, and DCE-MRI approach for distinguishing breast lesion types, compared to single-method models. Approach: Data from 33 confirmed breast lesions were analyzed retrospectively. MRI parameters (Ktrans, Kep, Ve, MK, MD, D) were compared across lesion types using ROC analysis. Results: Malignant lesions had significantly higher Ktrans, Kep, and MK values and lower D and MD values, with the combined model demonstrating superior diagnostic efficacy. Impact: The integration of IVIM, DKI, and DCE-MRI enhances diagnostic precision in breast lesion differentiation, potentially improving clinical decision-making and patient management by providing a more accurate non-invasive assessment, which could guide tailored treatment strategies for breast cancer patients.

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