Motivation: The pathogenesis of Alzheimer's disease (AD) remains unclear. Recently, abnormalities in brain energy metabolism associated with AD have attracted attention. Goal(s): This study aimed to gain insight into the background mechanisms of abnormal brain energy metabolism associated with AD pathology. Approach: We performed proteomic analysis in brain tissues derived from AD patients and AD model mice, and in vivo metabolic assessment with 1H MRS and hyperpolarized 1-13Cpyruvate MRS in AD model mice. Results: Impaired mitochondrial energy metabolism related to astrocyte was implied in the brain of AD patients and AD mouse model. Impact: This study provides insights into impaired mitochondrial energy metabolism associated with AD. Hyperpolarized 1-13Cpyruvate MRS detected hippocampal metabolic changes in AD mouse model at early pathological stages, and is expected to be applied to pathological studies of AD.
Ono et al. (Tue,) studied this question.