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September 17, 2025Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition

Impaired mitochondrial energy metabolism related to astrocyte in the brain of Alzheimer’s disease

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Authors

MOMaiko OnoKHKosei HirataRKRena Kono

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Overview

Proteomic analysis reveals impaired mitochondrial energy metabolism in Alzheimer's disease, highlighting the role of astrocytes.

Key Points

  • Impaired mitochondrial energy metabolism was observed in the brains of Alzheimer's disease patients and mouse models.
  • Using hyperpolarized [1-13C]pyruvate MRS, early hippocampal metabolic changes were detected in the AD mouse model.
  • The study involved proteomic analysis of brain tissues from Alzheimer's patients and various in vivo metabolic assessments.
  • These findings suggest potential biomarkers for early pathological changes in Alzheimer's disease.

Cite This Study

Ono et al. (2025) studied this question.

synapsesocial.com/papers/68d4597b31b076d99fa5cd0bhttps://doi.org/10.58530/2025/0570
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Metabolic Trans-Omic Analysis Reveals Key Regulatory Disruption of Energy Metabolism in Alzheimer's Disease2025
  2. 2An NMR-Based Protocol for Profiling the Endo- and Exo-Metabolomes in Aβ1-42 Treated Human Astrocytes from Healthy and Alzheimer’s Disease Donors2026
  3. 3Interrogating Aging Progression and Early Detection of Alzheimer’s Disease Using Metabolic Imaging2025
  4. 4Hyperpolarized 13C MRS detects brain metabolic alterations in a tauopathy model of Alzheimer’s disease2025
  5. 5Impaired Mitochondrial Energy Metabolism Regulated by p70S6K: A Putative Pathological Feature in Alzheimer’s Disease2024 · 3 citations