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September 12, 2025Alzheimer s & DementiaOpen Access

Metabolic dysregulation in Alzheimer's disease: A brain metabolomics approach

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Authors

AHAnke HülsYTYouran TanECEmma Casey

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Overview

High-resolution metabolomics reveals 155 metabolic features linked to Alzheimer's disease neuropathology, indicating genetic influences.

Key Points

  • The study identifies 155 metabolic features linked to alzheimer's disease, revealing critical pathways involved in its neuropathology.
  • Among the findings, 36 metabolic pathways were associated with alzheimer's disease, highlighting the complexity of its metabolic dysregulation.
  • High-resolution metabolomics profiling of 162 human brain samples from the ADRC enables the discovery of novel metabolites related to alzheimer's disease.
  • Genetic variability, especially in apolipoprotein E carriers, influences metabolic alterations, such as those in glucose and adenosine 5'-diphosphoribose.

Cite This Study

Hüls et al. (2025) studied this question.

synapsesocial.com/papers/68d44f6931b076d99fa5642ahttps://doi.org/10.1002/alz.70528
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Deciphering the metabolome in Alzheimer’s disease2026
  2. 2Dysregulation of multiple metabolic networks related to brain transmethylation and polyamine pathways in Alzheimer disease: A targeted metabolomic and transcriptomic study2020 · 166 citations
  3. 3Comprehensive metabolomics profiling reveals novel biomarkers and pathways for early detection of Alzheimer’s disease2025
  4. 4Multiomics analysis to explore blood metabolite biomarkers in an Alzheimer’s Disease Neuroimaging Initiative cohort2024 · 34 citations
  5. 5Metabolic Trans-Omic Analysis Reveals Key Regulatory Disruption of Energy Metabolism in Alzheimer's Disease2025